Lecture 11 - Biomolecular Engineering: General Concepts
Professor Saltzman starts the lecture with an introduction to pharmacokinetics and pharmacodynamics. Professor Saltzman talks about the concept of dose-response. He introduces different routes of drug administration and how they affect drug distribution and bioavailability (i.e., intravenous, oral, and sublingual routes). First-pass drug metabolism by the liver is also identified as an important source of drug degradation. Finally, modeling the body as a well-stirred vessel, Professor Saltzman explains the first-order rate equation: C = (M0/V)*e-kt, that can be used calculate the amount of drug in the body (M) as a function of time (t) and a rate constant (k); and the equation for drug half-life: t = ln(2/k).
Prof. W. Mark Saltzman
BENG 100 Frontiers of Biomedical Engineering, Spring 2008
(Yale University: Open Yale)
Date accessed: 2009-01-06
License: Creative Commons BY-NC-SA